Pharmacokinetics of Ephedrine Hydrochloride in Rats after Intragastric Administration of Shegan Mixtures
- VernacularTitle:灌胃射干合剂后大鼠体内盐酸麻黄碱药动学研究
- Author:
Yuenian TANG
;
Qihui CHEN
;
Zhiyan LIN
;
Xin WEI
;
Ting CHEN
;
Jian ZHANG
;
Xiaotong LU
;
Liang JIN
;
Chaorong SUN
;
Songhao HU
;
Chuanmin YANG
;
Yun YAN
- Publication Type:Journal Article
- Keywords:
Ephedrine hydrochloride;
Shegan mixtures;
Excretion;
Pharmacokinetics
- From:
China Pharmacist
2014;(4):553-555
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To determine the pharmacokinetics of ephedrine hydrochloride in rats after intragastric administration of Shegan mixtures. Methods:Shegan mixtures (1. 0 ml/100 g) were administered to each rat by gavage. Blood samples were collected after the administration. Plasma concentration of ephedrine hydrochloride was determined by LC-MS/MS. The pharmacokinetic parame-ters of ephedrine hydrochloride were obtained using the pharmacokinetic software. Urine and fecal samples were collected in 24 hours after the administration using metabolic cage to determine the recovery of ephedrine hydrochloride. Results: The pharmacokinetic pa-rameters of ephedrine hydrochloride were as follows:Tmax of (1. 30 ± 0. 23)h,T1/2 of (21. 17 ± 1. 35)h, Cmax of (278. 86 ± 46. 41)ng ·ml-1,AUC0~∞ of (1221.98 ±412.64)ng·ml-1 and Vc/F of (1.70 ±0.15)L. Totally 85.66% ephedrine hydrochloride could be recovered from urine in 24 hours after the administration;however, it was not detected in the fecal samples. Conclusion: Most of e-phedrine hydrochloride is excreted through kidney in 24h,therefore, Shegan mixtures can't cause the accumulation of ephedrine hydro-chloride in rats.
