Preparation, Characteristics and in vitro Drug Release of Silybin Lipid Emulsions
- VernacularTitle:水飞蓟宾脂肪乳的制备、性质及体外释药研究
- Author:
Penghua ZHANG
;
Jun LIANG
;
Jing ZHANG
;
Yongcheng DONG
- Publication Type:Journal Article
- Keywords:
Silybin;
Lipid emulsions;
Preparation;
Release in vitro
- From:
China Pharmacist
2014;(4):568-571
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To prepare silybin ( SLB) lipid emulsions and evaluate the drug release behavior in vitro. Methods:Silybin lipid emulsions were prepared by high-pressure homogenization method. Under the guidance of single-factor test, the best formula of SLB lipid emulsions was obtained by orthogonal design. Results:The encapsulation efficiency of SLB lipid emulsions prepared by the optimal formula was (91. 45 ± 0. 005 2) % with the particle size of (74. 42 ± 14)nm and PDI of 0. 106, Zeta potential of ( -30. 2 ± 2. 13)mV and pH of (6. 48 ± 0. 04). The drug release of SLB lipid emulsions was up to 90% within 12 hours. Conclusion:The opti-mized preparation of SLB with sustained-release property is obtained successfully.
