Meta-analysis of the C270T polymorphism of brain-derived neurotrophic factor gene in schizophrenia
10.3936/j.issn.1002-0152.2014.02.001
- VernacularTitle:精神分裂症患者BDNF基因C270T多态性Meta分析
- Author:
Shuxian HAN
;
Xianjiang ZHONG
;
Lili ZHANG
;
Xiao LUO
;
Zhiguo AN
;
Qizhong YI
- Publication Type:Journal Article
- Keywords:
Brain-derived neurotrophic factor;
Schizophrenia;
Polymorphism;
Single nucleotide;
Meta-analysis
- From:
Chinese Journal of Nervous and Mental Diseases
2014;45(2):65-70
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the relationship between the C270T polymorphism brain-derived neurotrophic factor and susceptibility of schizophrenia using meta-analysis. Methods A retrieval was performed on the case control study on the C270T polymorphism of the patients with schizophrenia. The meta-analysis was applied for investigating and summarizing the relationship between C270T polymorphism and schizophrenia. Subgroups were divided according to races. Results A total of 16 studies with 3874 patients and 4309 controls were included. The frequencies of C/T allele and genotype CC/(CT+TT) were associated with schizophrenia (all P<0.01) with OR 1.65 [95%CI (1.26, 2.16)] and 1.71 [95%CI (1.27, 2.30)], respectively. The association of C/T allele and genotype CC/(CT+TT) with schizophrenia was signif-icant in Asian subgroup (P<0.01), with OR 1.89 [95%CI (1.30, 2.75)] and 1.97 [95%CI (1.29, 3.03)], but not in Cauca-sian subgroup (all P=0.05). Conclusion The C270T polymorphism of brain-derived neurotrophic factor gene might con-tribute to the genetic susceptibility of schizophrenia in Asian population.
