Expression of N-cadherin protein in urothelial bladder cancer and its relation to prognosis
10.3760/cma.j.issn.1000-6702.2014.05.005
- VernacularTitle:膀胱尿路上皮癌组织中N-钙黏附素蛋白表达与预后关系的研究
- Author:
Lianhua ZHANG
;
Guoliang YANG
;
Juanjie BO
;
Dongming LIU
;
Yiran HUANG
- Publication Type:Journal Article
- Keywords:
Urinary bladder neoplasms;
Carcinoma;
Cadherins;
Prognosis
- From:
Chinese Journal of Urology
2014;35(5):337-340
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression and significance of N-cadherin in urothelial bladder cancer and analyse its relation to clinicpathologic and prognosis of bladder cancer.Methods The expression of N-cadherin in 145 urothelial bladder cancer and 25 normal bladder tissues was detected by immunuhistochemisty,and correlations between N-cadherin and clinicopathologic features were analysed.Results The positive rate of N-cadherin protein was significantly higher in bladder cancer than in normal bladder tissue (P＜0.01).The positive rate of N-cadherin protein was 38.6％ in G1 bladder cancer,58.4％ in G2-G3 bladder cancer,and its difference was significant (P =0.028).The expression was significantly lower in non-muscle-invasive bladder cancer than in muscle invasive bladder cancer (45.7％ vs 64.7％,P=0.029).The muscle-invasive bladder cancer patients were followed up 4-103 months.Among those,the overall survival with positive expression of N-cadherin protein was 24.2％ (8/33),and the overall survival with negative expression of N-cadherin protein was 66.7 ％ (12/18).Kaplan-Meier analysis showed the positive expression of N-cadherin was significantly associated with overall survival of patients with muscle-invasive-bladder cancer (P=0.002 2).Multivariate Cox analysis showed that N-cadherin expression was an important prognostic factor.Conclusions The expression of N-cadherin protein was high in bladder cancer.The detection of the expression of N-cadherin protein is associated with the diagnosis and prognosis of bladder cancer.
