Gender differences in patients with primary hyperparathyroidism concurrent with upper urinary tract calculus
10.3760/cma.j.issn.1000-6702.2014.04.007
- VernacularTitle:原发性甲状旁腺功能亢进伴上尿路结石患者代谢异常的性别差异
- Author:
Gang WANG
;
Wei YU
;
Xiaochun ZHANG
;
Liqun ZHOU
- Publication Type:Journal Article
- Keywords:
Hyperparathyroidism,primary;
Upper urinary tract calculi;
Metabolism;
Gender difference;
Hypercalciuria
- From:
Chinese Journal of Urology
2014;35(4):267-269
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the gender differences in patients with primary hyperparathyroidism (PHPT) concurrent with upper urinary tract stone.Methods The clinical data of 40 PHPT concurrent with upper urinary tract stone cases treated from January 1997 to December 2013 were analyzed retrospectively.There were 21 males and 19 females,with an mean age of 51 years (26-77 years).All patients underwent operation for PHPT,with preoperative parathyroid hormone (PTH) level of (38.42± 30.11)pmol/L.The PTH level in female patients was significantly higher than that in male patients (29.37± 17.64pmol/L versus 48.47±40.55 pmol/L,P=0.04).Serum biochemical variables were monitored,and 21 cases had 24 h-urinalysis.Results Postoperative pathology confirmed 36 cases of parathyroid adenoma and 4cases of parathyroid hyperplasia.Hypercalcemia and hypophosphatemia were improved with no significant gender difference (both P＞0.05).But in 21 cases of 24 h-urinalysis,urinary calcium and phosphorus in males were significantly higher than those in females (8.26±2.60 mmol/24 h versus 6.08± 1.59 mmol/24 h,P=0.03; 7.03±1.44 mmol/24 h versus 5.42±1.25 mmol/24 h,P=0.01).Conclusion In patients with PHPT concurrent with urolithiasis,male patients may be more associated with hypercalciuria.
