Preparation of polycaprolactone/poly (lactic acid-glycolic acid) biodegradable nano-structure ureteral stent and its degradation assay in vitro
10.3760/cma.j.issn.1000-6702.2014.04.014
- VernacularTitle:纳米梯度可降解输尿管支架的制备及体外降解性能研究
- Author:
Xiaoqing WANG
;
Yuchuan HOU
;
Qihui CHEN
;
Fengming JIANG
;
Yan WANG
;
Chunxi WANG
- Publication Type:Journal Article
- Keywords:
Polycaprolactone / poly(lactic acid-glycolic acid);
Ureter;
Stents;
Degradable;
Nanostructures
- From:
Chinese Journal of Urology
2014;35(4):293-296
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the preparation of a polycaprolactone (PCL)/poly (lactic acid-glycolic acid) (PLGA) degradable ureteral stent and its degradation ability in vitro.Methods From December 2010 to September 2012,degradable ureteral stent was fabricated by electrospinning,using different concentration of PCL/PLGA (5％,10％,15％,20％,25％,30％).The structure of stent was scanned by electron microscopy (SEM).The Instron system was used to test the mechanical property of those stents.The PCL/PLGA stents of different concentration (5％,15％,25％) were immerged into the urine to assess their degradable ability 7,14,21,28,35,42,49,56 days later.Results The inner diameter of the white tubular scaffold was 1.5 mm and the outer diameter was 2.0 mm.The SEM results showed that the scaffold had been made by nanofiber with the structure of multi-porous.The tension test showed that the mechanical property was enhanced with the increasing in the proportion of the PCL.The lowest stress at break was found in 5％ PCL/PLGA stent,while it was still sufficient for the mechanical criteria of degradable biomaterial.The degradation curves of different ratio of PCL/PLGA stent were close to a straight line.The 5％ PCL/PLGA stent collapsed into pieces within 28 d.The 15％ and 25％ PCL/PLGA collapsed within 42 d and 56 d,respectively.Conclusion The PCL/PLGA biodegradable ureteral stent has a good mechanical property and the degradation time can fully meet the demand of a ureteral stent.
