Assessment of diagnostic value of human epididymis secretory protein versus CA125 for endometrial cancer
10.3760/cma.j.issn.0254-9026.2014.04.020
- VernacularTitle:血清人附睾分泌蛋白4与癌抗原125在老年人子宫内膜癌诊断中的作用
- Author:
Jinghua LI
;
Tie ZHANG
;
Guozhen WANG
;
Haibo MA
;
Xinhui JING
;
Yongtong CAO
- Publication Type:Journal Article
- Keywords:
Endometrial neoplasms;
Epididymal secretory proteins;
Antigens,neoplasm
- From:
Chinese Journal of Geriatrics
2014;33(5):514-517
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the diagnostic value of human epididymis secretory protein (HE4) versus CA125 for endometrial cancer.Methods Serum HE4 and CA125 levels were measured by enzyme-linked immunosorbent assay (ELISA) and electrochemiluminescence immunoassay (ECLI) in 35 patients with endometrial cancer,48 patients with benign endometrial disorders and 40 healthy controls.The best cutoff value,sensitivity and specificity were calculated with pathological results as golden standard.Receiver operating characteristic curves were plotted,and areaunderthecurve (ROC-AUC) was used to compare diagnostic value of HE4 and CA125.Results The median value in HE4 in endometrial cancer were 51.46 pmol/L,which was significantly higher than in the healthy and benign disorder controls (25.65 pmol/L and 27.92 pmol/L).However,CA125 levels did not show statistically significant difference among the 3 groups.The ROC-AUC of HE4 for discriminating endometrial cancer between healthy controls and benign disorder controls were 0.922 and 0.759,respectively,which showed higher diagnostic value than CA125 (ROC-AUC of 0.590 and 0.457,respectively).HE4 had a specificity/sensitivity of 87.5％ /86.1％ for distinguishing healthy controls from endometrial cancer,and 95.5％ /50％ for differential diagnosis with benign disorders.Conclusions Measurement of HE4 can be used as a tumor marker for diagnosis of endometrial cancer.
