Expression changes of mucin1 and c-myc gene in elderly papillary thyroid carcinoma patient

VernacularTitle:多态性上皮黏蛋白1和原癌基因C-myc在老年甲状腺乳头状癌患者中的表达
Author: Yaojie HU ; Xiaoyan LUO ; Yue YANG ; Chunyou CHEN ; Zhiyong ZHANG ; Xin GUO
Publication Type:Journal Article
Keywords: Carcinoma,papillary; Thyroid neoplasms; Mucins1; Proto-oncogene proteins c-myc
From: Chinese Journal of Geriatrics 2014;33(5):496-498
CountryChina
Language:Chinese
Abstract: Objective To study the changes of expression of mucin1 (MUC1) and protooncogene proteins C-myc (C-myc) gene in elderly papillary thyroid carcinoma.Methods The expression levels of MUC1 and C-myc were examined by immunohistochemical methods in 58 sample of thyroid carcinoma,35 nodular goiter and in 30 normal thyroid tissue.Results The detective rate of MUC1 in 58 specimens of thyroid carcinoma was 77.6％ (45/58),while 90.0％ (9/10) in those with infiltration and 88.2 ％ (15/17) in those with metastasis.The detective rate of C-myc in 58 specimens of thyroid carcinoma was 81.0 ％ (47/58),and 100.0 ％ (17/17) in those with metastasis.Conclusions The differences in MUC1 or C myc expression and in thyroid carcinoma infiltration and lymph node metastasia between benign versus malignant thyroid tumor are statistically significant.