Effects of supplementing qi and activating blood circulation on platelet inhibition rate and platelet membrane glycoprotein in elderly patients with unstable angina pectoris undergoing percutaneous coronary intervention
10.3760/cma.j.issn.0254-9026.2014.05.009
- VernacularTitle:益气活血法对老年人不稳定型心绞痛经皮冠状动脉介入术后血小板聚集抑制率和血小板膜糖蛋白的影响
- Author:
Ping ZHANG
;
Hong ZHANG
;
Jingyuan MAO
- Publication Type:Journal Article
- Keywords:
Angina,unstable;
Platelet membrane glycoproteins;
Drugs,Chinese herbal;
Drug resistance
- From:
Chinese Journal of Geriatrics
2014;33(5):473-476
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of supplementing qi and activating blood circulation method(YQHX) on platelet inhibition rate and platelet membrane glycoprotein in elderly patients with unstable angina pectoris undergoing percutaneous coronary intervention(PCI).Methods Totally 177 elderly patients with unstable angina(qi deficiency and blood stasis syndrome) pectoris were randomized into two groups:90 cases in the treatment group and 87 cases in the control group.Both groups received conventional western medicinal treatment,for 14 days but YQHX was added to the treatment group.Platelet inhibition rate and platelet membrane glycoprotein were measured before and 14 days after treatment.Results After 14 days of treatment,the platelet inhibition rates induced by arachidonic acid (AA) and adenosine diphosphate (ADP) were significantly increased in the treatment group in comparison to pre-treatment and to control group respectively(P＜0.01).The prevalence of aspirin and clopidogrel resistance were lower in the treatment group than in the control group(8.9％ vs.21.8％,11.1％ vs.25.3％,both P＜0.05).After 14 days of treatment,the expression rates of CD62p,CD63 and PAC-1 were significantly lower in the treatment group than in pre-treatment and control group respectively (P＜0.01).Conclusions YQHX might effectively inhibit the platelet function and reduce the prevalence of aspirin and clopidogrel resistance in elderly patients with unstable angina pectoris undergoing the percutaneous coronary intervention.
