Retrospective analysis of the influence of clopidogrel combined with proton pump inhibitor on the prognosis of percutaneous coronary intervention

VernacularTitle:氯吡格雷联合质子泵抑制剂对冠状动脉内支架置入术后的影响分析
Author: Zhao XU
Publication Type:Journal Article
Keywords: Proton pump inhibitor; Stents
From: Chinese Journal of Geriatrics 2014;33(5):470-472
CountryChina
Language:Chinese
Abstract: Objective To observe the influence of clopidogrel combined with proton pump inhibitor (PPI) on the postoperative complication of percutaneous coronary intervention.Methods The clinical data of 600 patients who were taking clopidogrel antiplatelet therapy were retrospectively analyzed.All patients were divided into observation group (with PPI,n =300) and control group (without PPI,n=300).In-stent restenosis (ISR) and the adverse event rates were compared between the two groups during the period of follow up.Results The incidence of gastrointestinal bleeding was less in observation group than in control group (6.7％ vs.13.7％,x2 =8.048,P＜0.01),but the incidences of ISR,target vessel revascularization (TVR) and non-fatal myocardial infarction were higher in observation group than in control group(x2 =6.426、5.511、4.718,all P＜0.05).Conclusions Clopidogrel combined with PPI treatment can significantly reduce the risk of gastrointestinal bleeding,but increase the incidences of major adverse cardiovascular events.We suggest that PPI should be used with caution for the patients who need longer-term PPI use.