Clinical study on atorvastatin in the treatment of acute cerebral infarction in the elderly
10.3760/cma.j.issn.0254-9026.2014.05.004
- VernacularTitle:阿托伐他汀治疗老年急性脑梗死患者临床疗效观察
- Author:
Lin CHEN
- Publication Type:Journal Article
- Keywords:
Brain infarction;
Hydroxymethylglutaryl-CoA reductase inhibitors;
Aspirin
- From:
Chinese Journal of Geriatrics
2014;33(5):457-459
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical effect of atorvastatin on acute cerebral infarction treated with atorvastatin in the elderly.Methods 136 patients with acute cerebral infarction treated in our department from Oct.2011 to Nov.2012.And the patients were divided into observation group and control group.In observation group,68 cases were treated with conventional therapy plus Atorvastatin combined with aspirin.In control group,68 cases were treated with conventional therapy and aspirin.The clinical effect and safety were observed.Results In observation group versus control group,the cure rate (42.7％ vs.29.4％,x2 =2.584,P =0.108) and total effective rate (86.8％ vs.79.4％,x2 =1.821,P=0.177) showed no statistically significant differences.Posttreatment versus pre-treatment showed that neurological deficit score was improved both in observation group(t=18.621,P＜0.001) and in control group(t=15.026,P＜0.001) and activities of daily living improved both in observation group (t=10.544,P＜0.001)and in control group (t=8.815,P＜0.001).The differences of in neurological deficit score (t=1.179,P=0.120) and activities of daily living (t =0.321,P =0.374) were not statistically significance between the two groups.Before treatment,there were no significant differences in total cholesterol (TC),triglyceride (TG),low density-lipoprotein-cholesterol (LDL-C) and high-density-lipoprotein-cholesterol (HDL-C)between the observation group and the control group.After treatment,the difference in improvement of TC (t=8.446,P＜0.001),TG (t=4.145,P＜0.001),LDL-C (t=3.439,P=0.001) and HDL-C(t=2.718,P=0.004) between observation group and control group were statistically significant.Conclusions Atorvastatin combined with aspirin as add-on therapy to conventional therapy plus aspirin has better efficacy in the treatment of acute cerebral infarction in the elderly,and improve the blood lipid related indicators and life activity.
