Warfarin-induced Leukocytoclastic Vasculitis.
- Author:
Jae Hwan KIM
1
;
Se Yeong JEONG
;
Soo Hong SEO
;
Sang Wook SON
;
Il Hwan KIM
Author Information
1. Department of Dermatology, College of Medicine, Korea University, Seoul, Korea. kumcihk@korea.ac.kr
- Publication Type:Case Report
- Keywords:
Leukocytoclastic vasculitis;
Warfarin
- MeSH:
Aged;
Antigen-Antibody Complex;
Biopsy;
Female;
Glycosaminoglycans;
Humans;
Leg;
Purpura;
Skin;
Ticlopidine;
Ulcer;
Vasculitis;
Vasculitis, Leukocytoclastic, Cutaneous;
Warfarin
- From:Korean Journal of Dermatology
2008;46(5):715-717
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Leukocytoclastic vasculitis is a small vessel inflammatory disease, mediated mostly by deposition of immune complexes. Medications cause 10~24% of cases of leukocytoclastic vasculitic skin lesions, but warfarin has rarely been implicated. We report a case of warfarin-induced leukocytoclastic vasculitis in a 72-year-old woman which developed 45 days after warfarin medication. Palpable purpura, hemorrhagic vesicles, and ulcers developed on both lower legs. A skin biopsy showed characteristic features of leukocytoclastic vasculitis. Warfarin was replaced by clopidogrel, and the skin lesions gradually disappeared after 3 weeks.
