Mechamism of PAUF in pancreatic cancer pathogenesis and progression
10.3760/cma.j.issn.1007-8118.2014.04.022
- VernacularTitle:胰腺癌上调因子在胰腺癌发生、发展中的作用机制
- Author:
Chongchong GAO
;
Diangang LIU
;
Feng CAO
;
Fei LI
- Publication Type:Journal Article
- Keywords:
Pancreatic adenocarcinoma up-regulated factor (PAUF);
Pancreatic cancer;
Signal pathway;
Gemcitabine
- From:
Chinese Journal of Hepatobiliary Surgery
2014;20(4):317-320
- CountryChina
- Language:Chinese
-
Abstract:
Pancreatic adenocarcinoma up-regulated factor(PAUF),a newly discovered gene,is highly expressed in pancreatic cancer.PAUF promotes the metastasis and progression of pancreatic cancer through many ways,such as the activation of signal pathway (CXCR4,β-catenin,TPL2/MEK/ERK,FAK/Scr),increasing the adhesiveness of pancreatic cancer cells,promoting angiogenesis and vascular permeability.Simultaneously,CXCR4,β-catenin,TPL2/MEK/ERK and FAK/Scr are closely related with gemcitabine-resistance.Based on this theory,we infer that PAUF plays a role in gemcitabine-resistance of pancreatic cancer cells.So far,no related research has been done domestic and overseas.The research may find a clue for the mechanism of chemotherapy-resistance and provide a new target spot for the therapy of pancreatic cancer.
