Outcomes of tongue squamous cell carcinoma treated with different treatment modalities
10.3760/cma.j.issn.1004-4221.2014.03.017
- VernacularTitle:舌体鳞状细胞癌不同治疗模式疗效分析
- Author:
Boqing WANG
;
Pan LIU
;
Huarong ZHAO
;
Niyazi HUERXIDAN
;
Songan ZHANG
;
Yongxing BAO
- Publication Type:Journal Article
- Keywords:
Tongue neoplasms/surgery;
Tongue neoplasms/radiotherapy;
Tongue neoplasms/chemotherapy;
Tongue neoplasms/combined modality therapy;
Prognosis
- From:
Chinese Journal of Radiation Oncology
2014;23(3):244-247
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the therapeutic effects of different treatment modalities in patients with tongue squamous cell carcinoma.Methods A retrospective analysis was performed on the complete clinical and follow-up data of 132 patients with pathologically confirmed tongue squamous cell carcinoma,who were initially treated at the First Affiliated Hospital of Xinjiang Medical University from 2003 to 2011.The Kaplan-Meier method was used to calculate the overall survival (OS) rates for patients who received surgery alone (S),radiotherapy alone (R),surgery plus radiotherapy (S + R),chemotherapy plus surgery (C + S),chemotherapy plus radiotherapy (C + R),and surgery,radiotherapy,and chemotherapy (S + R + C).The OS was compared between these groups by log-rank test.Multivariate analysis was performed using the Cox proportional hazard model to establish independent treatment modalities as prognostic factors.Results The follow-up rate was 100％.The 3-year sample size was 94.The 3-year OS rate for all patients was 72.7％.The univariate analysis showed that among 70 stage Ⅰ and Ⅱ patients,the S,R,S + R,C + S,and S + R + C groups had 3-year OS rates of 86％,67％,97％,100％,and 82％,respectively (P =0.018) ;among 62 stage Ⅲ and Ⅳ patients,the S,R,S + R,C + S,C + R,and S + R + C groups had 3-year OS rates of 38％,14％,92％,40％,14％,and 67％,respectively (P =0.000).The multivariate analysis showed that S + R and S + R + C were independent prognostic factors (P =0.000 and 0.005).onclusions Surgery alone or combination therapy including surgery has a good therapeutic effect for stage Ⅰ-Ⅱ tongue squamous cell carcinoma,while S + R and S + R + C are better treatment modalities for stage Ⅲ-Ⅳ disease;however,advanced patients have a poor prognosis after being treated with R and C + R modalities.
