Clinical observation of acute skin and oral mucous membrane reactions in patients with nasopharyngeal carcinoma treated with concurrent radiochemotherapy and correlated factors
10.3760/cma.j.issn.0254-5098.2014.05.008
- VernacularTitle:鼻咽癌同期放化疗中急性皮肤黏膜反应的临床观察及其相关因素分析
- Author:
Hao CHENG
;
Hui WU
;
Xiaoxu LU
;
Jing XU
- Publication Type:Journal Article
- Keywords:
Nasopharyngeal carcinoma;
Intensity modulated radiotherapy;
Acute mucosal reaction;
Acute skin reaction
- From:
Chinese Journal of Radiological Medicine and Protection
2014;34(5):351-354
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the acute skin and mucous membrane reactions in patients treated with concurrent radiochemotherapy for nasopharyngeal carcinoma,and to analyze the influencing factors.Methods A total of 85 nasopharyngeal carcinoma cases treated with concurrent radiochemotherapy were enrolled in the study.Fifteen clinical and laboratory indexes,including BMI,radiation dose,degree of acute oral mucous and skin reactions and blood routine test were observed weekly.Univariate and multivariate regression analysis were performed to assess the factors,and screen the independent factors.Results Multiple-factor analysis showed that the risk factors cloesly related with acute radioactive oral mucosa reactions were smoking history(OR =3.467,P ＜ 0.05),single-dose of gross tumor volume (GTV) ＞2.15 Gy(OR =3.393,P ＜ 0.05),while those with acute radiation skin reactions were diabetes history(OR =87.859,P ＜ 0.05) and hemoglobin values 1 week before radiotherapy ＞ 130 g/L (OR =21.404,P ＜ 0.05).Conclusions In the patients treated with concurrent radiochemotherapy for nasopharyngeal carcinoma,smoking history and single-dose of GTVnx is the independent risk factors of acute radiation oral mucosa reactions,while diabetes history and hemoglobin values I week before radiotherapy are the independent factors of acute skin reactions.
