Research on ultrasound microbubble destruction technology increases the therapeutic effect of laser ablation rabbit VX2 liver tumor
10.3760/cma.j.issn.1004-4477.2014.04.018
- VernacularTitle:超声微泡击破技术增效激光消融兔肝VX2肿瘤的实验研究
- Author:
Bin YANG
;
Feng FU
;
Xiaodong ZHOU
;
Ming YU
;
Guangbin HE
;
Jianguo HE
;
Hongzhi ZHENG
- Publication Type:Journal Article
- Keywords:
Sonication;
Microbubbles;
Laser coagulation;
Liver neoplasms
- From:Chinese Journal of Ultrasonography
2014;23(4):345-348
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the basis of ultrasound microbubble technology enhanced thermal ablation effect.Methods All 48 rabbits bearing hepatic tumors were averagely randomly divided into four groups:only laser group,sham,destruction + laser group,and blank group.The filling defect area changes of before and after treatment were observed and the differences between groups were compared.Results Pathology confirmed ablation of tumor tissue could produce coagulation necrosis for experiment group.The conventional ultrasound showed there was no significant variation in the maximum diameter and area in the pre and post treatment of experiment group and control group(P ＞0.05).There was no change for the control group.Ultrasound imaging showed an area of filling defect were:laser treatment alone group (0.83 ± 0.06) cm2,microbubbles false break combined with laser therapy group (0.65 ± 0.05) cm2,microbubbles break combined with laser therapy group (2.40 ± 0.16)cm2,blank control group (0.01 ± 0.01) cm2.The filling defect area of the treatment group,which was combined with ultrasound microbubble break technology and laser ablation was increased,there was significant variation in the each group (P ＜0.05).Conclusions Microbubble burst combined laser ablation could expand the single needle laser ablation area of rabbit VX2 liver tumor and increase the therapeutic effect.
