Adiponectin gene SNP 276G --> T, nutrient intakes, and cardiovascular disease risk in Korean type 2 DM patients.
- Author:
So Young YU
1
;
Han Kyoung RYU
;
Hee Jung PARK
;
Young Ju CHOI
;
Kap Bum HUH
;
Wha Young KIM
Author Information
- Publication Type:Original Article
- Keywords: Adiponectin SNP 276G-->T; adiponectin; insulin resistance; type 2 diabetes; cardiovascular disease risk factors
- MeSH: Adiponectin*; Body Weight; C-Reactive Protein; Cardiovascular Diseases*; Diabetes Mellitus, Type 2; Genotype; Humans; Insulin Resistance; Male; Polymorphism, Single Nucleotide; Prevalence; Surveys and Questionnaires; Risk Factors; Seoul; Waist Circumference; Waist-Hip Ratio
- From:Nutrition Research and Practice 2007;1(4):363-370
- CountryRepublic of Korea
- Language:English
- Abstract: Single nucleotide polymorphism (SNP) in adiponectin gene has been associated with insulin resistance, diabetes, and cardiovascular disease (CVD). This study was performed to investigate the association of SNP 276G-->T at adiponectin gene with CVD risk factors in Korean type 2 diabetes mellitus (DM) patients. The subjects were 351 type 2 DM patients visited a DM clinic in Seoul, and the patients with known CVD were excluded. The adiponectin SNP 276G-->T was analyzed and dietary intakes were assessed by a Food Frequency Questionnaire. The prevalence of G/G, G/T, and T/T genotype was 47.6%, 43.3%, and 9.1%, respectively. Male subjects with T/T genotype showed significantly lower level of adiponectin and HDL-cholesterol and significantly higher C-reactive protein (CRP) level compared to G/G and G/T genotypes. In G/G genotype, protein intake was negatively correlated to body weight, BMI, and waist circumference, and there were positive correlation between carbohydrate intake and BMI, waist-hip ratio, and ApoB/apoA-1 ratio in G/T genotype. However, in T/T genotype, there was no significant association between macronutrient intakes and anthropometric and hematological values. In conclusion, CVD risk would be high in type 2 DM patients with T/T genotype, and the association of macronutrient intakes with anthropometric and hematologic factors was different among the three adiponectin genotypes. These results may imply the need for different dietary management regime according to adiponectin genotype to lower CVD complications in Korean type 2 DM patients.
