Collagen/bioactive glass/chitosan composite scaffolds
10.3969/j.issn.2095-4344.2014.21.016
- VernacularTitle:胶原/生物活性玻璃/壳聚糖增强型复合支架
- Author:
Yongchun MENG
;
Xiaofeng CHEN
;
Kaihui NAN
;
Yuli LI
;
Xiaogang LUO
;
Chunlin DENG
- Publication Type:Journal Article
- Keywords:
biocompatible materials;
chitosan;
col agen;
glass
- From:
Chinese Journal of Tissue Engineering Research
2014;(21):3367-3373
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:Col agen/bioactive glass composite materials possess excellent osteogenic potential and biocompatibility, but its application in bone tissue engineering is limited by mechanical property and degradation. OBJECTIVE:To construct col agen/bioactive glass/chitosan composite scaffolds with good mechanical property, anti-degradation ability and bone repair property.
METHODS:Bioactive glass/col agen composite scaffolds with chitosan as dispersant were prepared by lyophylization. Fourier transform infrared spectroscopy, scanning electron microscope, X-ray diffraction, and dynamic biomechanical testing were used to characterize the structure and properties of the composite scaffolds. RESULTS AND CONCLUSION:Results show that charge-attractions in pre-prepared bioactive glass/chitosan solution increased the homogeneity of bioactive glass dispersed in col agen gel and the compressive modulus and strength increased significantly due to the homogeneity and intermolecular interactions between chitosan and col agen. The enzymatic degradation rate and mineralization activity in the simulated body fluid were also lower because of a high degree of embedment of bioactive glass in col agen/chitosan matrix, and entanglement of col agen in chitosan at molecular level, which decreased the exposure of bioactive glass to the simulated body fluid, and col agen to enzyme solution.
