Smoking promotes the resorption of periodontal alveolar bone
10.3969/j.issn.2095-4344.2014.20.011
- VernacularTitle:吸烟促进牙周炎牙槽骨的吸收效应
- Author:
Jianhua ZHU
;
Ying WANG
;
Zhongnan ZHAO
;
Jiguang LIU
- Publication Type:Journal Article
- Keywords:
smoking;
periodontitis;
alveolar bone loss;
NF-kappa B;
osteoprotegrin
- From:
Chinese Journal of Tissue Engineering Research
2014;(20):3172-3177
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:Various studies confirm that smoking can contribute to the resorption of periodontal alveolar bone.
OBJECTIVE:To observe the effect of smoking in alveolar bone resorption of periodontitis rat models.
METHODS:A total of 24 rats were randomly divided into three groups. Normal group:rats were normal y fed without any other pre-treatment;Control group:experimental periodontitis model was established using wire ligation method in rats;Experimental group:rat models were given passive smoking during experimental
modeling period. Al rats were sacrificed after 8 weeks of modeling, periodontal tissue were removed. Hematoxylin-eosin staining was used for examining pathological changes in periodontal tissue, and immunohistochemical analysis was done for observing receptor activator of nuclear factor-κB ligand and osteoprotegrin expression.
RESULTS AND CONCLUSION:After 8 weeks of modeling, expression of receptor activator of nuclear factor-κB ligand factor was significantly higher in alveolar bone of rats from experimental group in comparison to control group (P<0.05), whereas expression of osteoprotegerin in alveolar bone was significantly greater in rats from control group when compared to experimental group (P<0.05). This finding suggests that smoking can increase the expression of receptor activator of nuclear factor-κB ligand protein and reduce osteoprotegrin expression in periodontal rats, thus increasing the resorption of periodontal alveolar bone.
