Diabetes mellitus and bone metabolic disorders:valuable prevention and treatment
10.3969/j.issn.2095-4344.2014.20.027
- VernacularTitle:骨代谢紊乱与糖尿病：有价值的防治并举
- Author:
Chen KANG
;
Bin ZHANG
;
Yao SUN
- Publication Type:Journal Article
- Keywords:
diabetes mel itus;
osteoporosis;
bone disease,metabolic;
fractures
- From:
Chinese Journal of Tissue Engineering Research
2014;(20):3263-3268
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:Diabetes mel itus can give rise to bone metabolic disorders in patients, resulting in the occurrence of osteoporosis and low traumatic fractures. However, the pathogenesis mechanism remains unclear. OBJECTIVE:To review the current research progress in the bone metabolic disorders resulting from diabetes mel itus, and to provide theoretical basis of the prevention and treatment of diabetic osteopathy. METHODS:A computer-based online search was conducted in Pubmed database (http://www.ncbi.nlm.nih.gov/pubmed/) from January 2000 to December 2013. Articles focusing on diabetes mel itus regulating bone metabolism were col ected using the key words of“diabetes mel itus;bone”in English. High-quality relevant studies were included, while repetitions and unidirectional studies were excluded.
RESULTS AND CONCLUSION:A total of 6 979 articles were obtained initial y, and after screening procedures 58 literatures were selectively included in this review. Although type 1 and type 2 diabetes mel itus exert different effects on the bone mineral density, they ultimately result in osteoporosis and low traumatic fractures. It is widely believed that the pathogenesis may be that high glucose breaks the balance between bone formation and bone absorption, so that bone absorption is greater than bone formation. The number of the osteoclasts is increased, while the cytokines of promoting osteogenesis are restrained. As a consequence, those result in low bone mineral density, brittle bone and high incidence of fracture.
