A research of correlation between renal damage of patients with gestational diabetes mellitus and level of serum cystatin C
10.3969/j.issn.1673-4130.2014.10.024
- VernacularTitle:妊娠期糖尿病患者肾损害与血清Cys C水平的相关性研究
- Author:
Xiantao QIU
;
Yuanyuan QIU
;
Yumei DAI
;
Xiaoqiong GU
;
Sujuan ZHANG
;
Minmin CAI
- Publication Type:Journal Article
- Keywords:
diabetes,gestational;
renal damage;
cystatin C;
urinary protein
- From:
International Journal of Laboratory Medicine
2014;(10):1289-1290
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlation between renal damage of patients with gestational diabetes mellitus (GDM ) and level of serum cystatin C(Cys C) .Methods Eutocia puerperas with single birth in this center from January 2011 to December 2012 were retrospectively analyzed .400 puerperas ,who were confirmed as GDM by oral glucose tolerance test (OGTT) detection ,were collected .Among them ,200 puerperas with 24 h urinary protein content more than 0 .15 g during their 30 to 40 weeks of pregnancy were served as GDM group ,while another 200 puerperas with those not more than 0 .15 g as GDM control group .200 healthy puer-peras without GDM were served as the normal group .Serum uric acid ,creatinine ,urea ,Cys C and 24 h urinary protein content of them during their 30 to 40 weeks of pregnancy were detected .Results Serum uric acid and Cys C of patients in GDM group were obviously higher than those in the GDM control group(P<0 .05) ,while the differences of serum urea ,creatinine between the two groups showed no statistical significance (P>0 .05) .24 h urinary protein content was positively correlated with the serum uric acid and Cys C(r=0 .715 ,0 .863 ,P<0 .05) ,and had no correlation with urea and creatinine (P>0 .05) .Conclusion Serum Cys C may be used as indicators for early diagnosis and monitoring of renal damage in patients with GDM .
