Reelin protein expression in peripheral blood of patients with schizophrenia
10.3969/j.issn.1673-4130.2014.10.025
- VernacularTitle:精神分裂症患者外周血液中Reelin蛋白的表达
- Author:
Leiguang FENG
;
Hongyan CAO
;
Pingping QI
;
Na ZHAO
;
Hong ZHANG
;
Zhiwei SONG
- Publication Type:Journal Article
- Keywords:
schizophrenia;
protein,Reelin;
blotting,Western
- From:
International Journal of Laboratory Medicine
2014;(10):1291-1292
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between the Reelin protein and schizophrenia .Methods 89 patients with schizophrenia were served as schizophrenic group and 89 healthy people as control group .Western blot was employed to detect their peripheral blood Reelin protein expression .Results The expression level of peripheral blood Reelin protein of patients in schizo-phrenic group(0 .66 ± 0 .27) was significantly lower than that in the control group(1 .01 ± 0 .23)(P<0 .05) .Reelin protein expres-sion levels of male and female patients in schizophrenic group were 0 .66 ± 0 .22 and 0 .66 ± 0 .26 ,respectively ,with no statistically significant difference(t=0 .181 ,P>0 .05) .Reelin protein expression levels of male and female subjects in the control group were 1 .01 ± 0 .25 and 1 .02 ± 0 .26 ,respectively ,with also no statistically significant difference (t=0 .201 ,P>0 .05) .Conclusion The low expression level of Reelin protein is related to schizophrenia .
