Clinical significance of HLA-B27 detection in diagnosis of ankylosing spondylitis
10.3969/j.issn.1673-4130.2014.10.022
- VernacularTitle:HLA-B27检测对强直性脊柱炎诊断的临床意义
- Author:
Yongjie LIU
;
Xiaogfang ZHANG
;
Yungang ZHANG
;
Haixin LI
;
Shouxia LI
- Publication Type:Journal Article
- Keywords:
flow cytometry;
spondylitis,ankylosing;
HLA antigens
- From:
International Journal of Laboratory Medicine
2014;(10):1285-1286
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the diagnostic value of human leukocyte antigen (HLA )-B27 for ankylosing spondylitis (AS) .Methods 2 768 patients with suspected AS were enrolled ,including 600 patients with confirmed AS .Flow cytometry was performed to detect blood HLA-B27 .Results Among 2 768 patients with suspected AS ,598(21 .6% ) patients were found HLA-B27 positive and 2 170(78 .4% ) patients negative .Difference of HLA-B27 positive rates between male and female patients was sta-tistically significant(P< 0 .05) .HLA-B27 positive rate of patients aged 20 - < 40 years was significantly higher than the others (P<0 .05) .Among 600 patients with confirmed AS ,536 cases(89 .3% ) was found HLA-B27 positive .Conclusion HLA-B27 de-tection combined with clinical manifestations contribute to early diagnosis of AS .
