Quality Control of Residual Solvents in 18FFDG Preparations by Gas Chromatography.
- Author:
Hak Jeong LEE
1
;
Jae Min JEONG
;
Yun Sang LEE
;
Hyung Woo KIM
;
Young Soo CHANG
;
Dong Soo LEE
;
June Key CHUNG
;
Myung Chul LEE
Author Information
1. Department of Nuclear Medicine, College of Medicine and Institute of Radiation Medicine, Medical Research Center, Seoul National University, Korea. jmjng@snu.ac.kr
- Publication Type:Original Article
- Keywords:
residual solvents;
[18F]FDG;
gas chromatography;
quality control
- MeSH:
Chromatography, Gas*;
Ethanol;
Quality Control*;
Solvents*;
Volatile Organic Compounds
- From:Nuclear Medicine and Molecular Imaging
2007;41(6):566-569
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Analysis of volatile organic solvents in 2-deoxy-2-[18F] fluoro-D-glucose ([18F]FDG) preparations was performed by gas chromatography (GC), in accordance with USP. MATERIALS AND METHODS: Analyses were carried out on a Hewlett-Packard 6890 gas chromatography equipped with an FID. RESULTS: We determined the amounts of ethanol and acetonitrile on every batch of our routine [18F]FDG preparations, ranging between 5000 ppm and 100 ppm. In our routine preparation of [18F]FDG, the amount of acetonitrile and ethanol in the final product were well below the maximum allowable limit described in the USP. CONCLUSION: Our [18F]FDG preparations were in accordance with the suggested USP maximum allowable levels of the quality control analysis of volatile organic compounds.
