Clinical utility of tuberculosis protein chip in diagnosis of tuberculosis
- VernacularTitle:结核蛋白芯片检测诊断结核病的价值
- Author:
Yougen WU
;
Xingping YANG
;
Jun WANG
;
Hongbing LIU
;
Juhua LUO
;
Bi YU
;
Shuyuan XIAO
;
Li ZHANG
;
Chaojin LI
- Publication Type:Journal Article
- Keywords:
Mycobacterium tuberculosis;
protein chip;
antibody
- From:
Chinese Journal of Infection and Chemotherapy
2014;(3):196-198
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the potential value of tuberculosis protein chip for clinical diagnosis of tuberculosis.Methods The antibody level of tuberculosis protein ESAT-6,CFP10,16 KD,38 KD and LAM was determined in 4 093 patients,inclu-ding 441 tuberculosis and 3 652 non-tuberculosis cases by protein chip.Results The tuberculosis antibody was positive in 297 of the 441 tuberculosis cases and 647 of the 3 652 non-tuberculosis cases.Tuberculosis protein chip provided a sensitivity of 67.35% and specificity of 82.28% in the diagnosis of tuberculosis.Conclusions Tuberculosis protein chip test is a quick,easy and effective method for identifying potential tuberculosis patients with good specificity.
