In vitro activity of fosfomycin tromethamine against Enterobacteriaceae isolates from urine
- VernacularTitle:磷霉素氨丁三醇对尿标本中肠杆菌科细菌体外抗菌活性研究
- Author:
Jingyong SUN
- Publication Type:Journal Article
- Keywords:
urinary tract infection;
Enterobacteriaceae;
fosomycin tromethamine
- From:
Chinese Journal of Infection and Chemotherapy
2014;(2):153-156
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the in vitro activities of antimicrobial agents including fosfomycin tromethamine against Enter-obacteriaceae isolates from urine samples and provide evidence for reasonable use of antibiotics.Methods A total of 1 185 Enter-obacteriaceae isolates from midstream urine samples were identified by ATB system.Antimicrobial susceptibility and ESBLs production were tested by Kirby-Bauer method.The results were analyzed according to the breakpoints of CLSI 2012.WHO-NET 5.6 software was used to retrospectively analyze the distribution and antibiotic susceptibility of pathogenic bacteria.Re-sults Overall,about 90.8% of the 1 185 isolates tested were susceptible to fosfomycin tromethamine.The top three species of bacteria showing the highest suceptibility rate to fosfomycin tromethamine were Escherichia coli (93.1%),Klebsiella pneu-moniae (88.7%),and Proteus spp.(79.7%).The Enterobacteriaceae isolates from urine samples of inpatients were less sus-ceptibe to the antimicrobial agents tested compared to the isolates from outpatients (87.0% versus 92.7% susceptible).ESBLs were identified in 54.4% of Escherichia coli ,38.7% of Klebsiella pneumoniae and 23.2% of Proteus strains.The ESBL-pro-ducing E.coli (89.5%)and K.pneumoniae (87.5%)were highly susceptible to fosfomycin tromethamine.Conclusions Esch-erichia coli is the most popular Enterobacteriaceae isolated from urine samples.Fosfomycin tromethamine has good in vitro an-tibacterial activity against Enterobacteriaceae strains,including ESBLs-producing E.coli and K.pneumoniae.Fosfomycin tromethamine is a valuable therapeutic option for urinary tract infections.
