Clinical evaluation of a two-step infusion therapy with meropenem against nosocomial multi-drug resistant Pseudomonas aeruginosa infections in elderly patients with chronic obstructive pulmonary disease
10.3760/cma.j.issn.1008-6706.2014.07.003
- VernacularTitle:美罗培南两步输注法治疗老年人慢性阻塞性肺疾病并铜绿假单胞菌肺炎疗效分析
- Author:
Yanping LYU
;
Jiong LIU
;
Chunxiang PAN
;
Xianju FENG
;
Dong YU
;
Zhenzhen LIANG
- Publication Type:Journal Article
- Keywords:
Pseudomonas aeruginosa;
Medication;
Pulmonary disease,chronic obstructive;
Multi-drug
- From:
Chinese Journal of Primary Medicine and Pharmacy
2014;(7):966-967
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy of a two-step infusion therapy with meropenem against noso-comial multi-drug resistant Pseudomonas aeruginosa infections in elderly patients with chronic obstructive pulmonary disease.Methods 112 elderly patients with nosocomial multi-drug resistant Pseudomonas aeruginosa infections and chronic obstructive pulmonary disease were randomized into two groups:two-step infusion therapy group ( rapid first-step infusion in 30 minutes and slow second-step infusion in 2.5 hours) and traditional 30 minutes infusion therapy group.The antibiotic clinical efficacy and bacteriological efficacy were observed between two groups .Results The clinical efficacy of observation group and control group were 82.2%(46/56) vs 57.1%(32/56).The difference was statistically significant(χ2 =10.185,P<0.05);The bacteriological efficacy of observation group and control group were 75.0%(42/56) vs 46.4%(26/56),The difference was statistically significant (χ2 =10.265,P<0.05). Conclusion The clinical efficacy and bacteriological efficacy of two-step infusion therapy with meropenem against nosocomial multi-drug resistant Pseudomonas aeruginosa infections in elderly patients with chronic obstructive pulmo -nary disease were superior to the traditional therapy .
