Expression levels and significance of matrix metalloproteinases 9 (MMP-9) in the placenta of preeclampsia
10.3969/j.issn.1006-5725.2014.06.033
- VernacularTitle:子痫前期患者胎盘基质金属蛋白酶-9的表达及其意义
- Author:
Fang ZHANG
;
Xiaoshu LI
- Publication Type:Journal Article
- Keywords:
Preeclampsia;
Matrix metalloproteinases 9;
Placental weight;
Neonatal weight
- From:
The Journal of Practical Medicine
2014;(6):938-940
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the relationship between matrix metalloproteinases 9 (MMP-9) and the pathogenesis of preeclampsia , birth weight and placental weight , through detecting the expression of MMPS-9 in the placenta of the patients with preeclampsia. Methods The levels of MMP-9 in the placenta were detected by immunohistochemical SP method in 60 patients with preeclampsia and 30 pregnancy women. Results (1) The optical density value of MMP-9 in preeclampsia group was lower than the control group , the optical density value of MMP-9 in SPE group was lower than the MPE group (P < 0.05). (2) The placenta weight and birth weight in preeclampsia group were lower than the control group , the placenta weight and birth weight in SPE group was lower than the MPE group (P < 0.05). (3) The expression level of MMP-9 were positively correlated with placental weight and birth weight (P < 0.05) in the control group. (4) The average optical density value of MMP-9 in neonatus with weight < 2 500 g was lower than neonatus with weight≥2 500 g (P < 0.05). Conclusion The MMP-9 in the placenta of patients with preeclampsia was down-regulated , and its expression was abate when the illness grew worse. The MMP-9 may be involved in the pathogenesis of preeclampsia , and it is associated with fetal growth restriction.
