Evaluation of ACL TOP coagulation analytical system in the laboratory of children′s hospital
10.3969/j.issn.1006-5725.2014.06.042
- VernacularTitle:ACL TOP血凝仪在儿科实验室的应用评价
- Author:
Yueping WU
;
Lixia XIAO
;
Qingbin YANG
;
Defeng CAI
;
Dongli MA
- Publication Type:Journal Article
- Keywords:
Coagulation analyzer system;
Reference interval;
Paediatrics
- From:
The Journal of Practical Medicine
2014;(6):965-969
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the performance of ACL TOP coagulation analyzer system in the laboratory of children′s hospital. Methods According to the documents of CLSI, the analytic characteristics including precision, accuracy, linearity, interference and carryover rate were examined; specimens from healthy children were collected and assayed to determine the reference range of Prothrombin Time (PT), Activated Partial Thromboplastin Time (APTT), Thrombin Time (TT), Fibrinogen (FIB) and D-Dimer (D-D) from children on ACL TOP. Results The within-run and between-day coefficient of variability (CV) were within an acceptable range; The accuracy deviation of PT , APTT and FIB were less than 1/2 allowed total errors; The results of determination of FIB linearity test were correlated with the results of calculation: Y = 1.002 1X-0.122, R2 =0.998 2; The extent of influence of low to middle grade of jaundice , fat and hemolysis on each test were all less than 1/2 allowed total error; The carryover rates were lower than 1.81% and within an acceptable range; The reference range of PT, APTT, TT and FIB were PT (9.1-13.1 s), APTT (24.9-42.1 s), TT (12.6-21.1 s), FIB (1.924-4.011 g/L). Conclusion The ACL TOP coagulation analyzer has good repeatability, stability, linearity and capability of anti-interference and anti-carryover.
