Evaluation of combination therapy with vitamin E and vitamin C for idiopathic asthenospermia by Q value method
10.3969/j.issn.1006-5725.2014.05.020
- VernacularTitle:金正均Q值法评价维生素C联合维生素E治疗特发性弱精子症的协同作用
- Author:
Peng HAN
;
Zhiwen LIU
;
Guogang ZHANG
;
Shouyun XIAO
;
Hong XU
;
Jiulin WANG
- Publication Type:Journal Article
- Keywords:
Asthenozoospermia;
Vitamin E;
Vitamin C;
Reactive oxygen species;
MDA;
Synergistic interaction;
Q value
- From:
The Journal of Practical Medicine
2014;(5):738-741
- CountryChina
- Language:Chinese
-
Abstract:
Objective To use Q value method to assess the effect of combination therapy with vitamin E and vitamin C for idiopathic asthenospermia. Methods 76 patients diagnosed as idiopathic asthenospermia by computer-assisted semen analysis according to the WHO criteria were selected at the andrology clinic from August 2012 to November 2013. Malondialdehyde (MDA) concentration was measured by using thiobarbituric acid (TBA) assay. The patients were randomly divided into three groups. Vit C group received vitamin C 200 mg thrice daily, vit E group received vitamin E 100 mg thrice daily , and the combination group received vitamins E and C for 12 weeks. Repeat semen analysis and MDA measurement were conducted after treatment, and the Q value which evaluated whether a synergistic interaction existed was calculated. Results MDA concentration decreased in all the groups, with the lowest concentration in the combination group. While all the groups achieved improvement in term of progressive motility , with the combination group presented far more better than the other two groups , exhibiting a synergistic interaction, with a Q value of 1.18. Conclusion Combination therapy with vitamin E and vitamin C has a marked internal synergistic effect on antioxidation in the treatment of idiopathic asthenospermia.
