Target in target radiotherapy for 90 patients with spinal metastases

VernacularTitle:靶中靶放射治疗脊柱转移癌90例
Author: Lina ZHANG ; Tingting HAN ; Hongqi LI ; Yingjie WANG ; Weizhang WU ; Tingyi XIA
Publication Type:Journal Article
Keywords: Spinal neoplasms; Spinal metastases; Target in target radiotherapy; Pain
From: The Journal of Practical Medicine 2014;(5):789-791
CountryChina
Language:Chinese
Abstract: Objective To analyze the result of dose-escalated radiotherapy vs conventional radiotherapy for spinal metastases. Methods Ninety patients (118 lesions) underwent radiotherapy..There were 52 patients (63 lesions) in target in target radiotherapy (TIT) receiving PTV 30~40 Gy, GTV 50~60 Gy/15~25 f. 38 patients (55 lesions) received PTV 30~40 Gy/10~20 f in the conventional radiotherapy. Results The overall responses were 90.4% and 81.6%,respectively.but no significant difference was found. There were 31 and 25 improved lesions, 28 and 20 steady lesions, 4 and 10 worsening lesions,in two goups, respectively. 1-year local control rates and survival were 84.7%vs 68.6%and 49.4%vs 32.2%, respectively. The significant differences were found in 1-year local control rates and survival. The main acute adverse reactions were mainly hematologic toxicities , no significant difference was found. Conclusion TIT for spinal metastases is a more safe and effective treatment, with better efficacy and fewer side-reactions.