Comparison on Intestinal Absorption of Pectolinarin and Pectolinarigenin by Everted Rat Intestinal Sac Method
10.11842/wst.2014.02.025
- VernacularTitle:柳穿鱼叶苷和柳穿鱼黄素的大鼠肠外翻吸收研究
- Author:
Qi CHEN
;
Feipeng GONG
;
Zhaohua LIU
;
Lingyun ZHONG
;
Qianfeng GONG
- Publication Type:Journal Article
- Keywords:
Carboned Cirsium japonicum DC;
pectolinarin;
pectolinarigenin;
everted rat intestinal sac method
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2014;(2):352-357
- CountryChina
- Language:Chinese
-
Abstract:
This article was aimed to study the intestinal absorption about main active ingredients of pectolinarin and pectolinarigenin in Carboned Cirsium japonicum DC. The absorption rate and absorption rate constant were taken as indicators. The intestinal absorption of pectolinarin and pectolinarigenin were compared by everted rat intestinal sac method among different parts of the small intestine. The results showed that the absorption rate constant of pectoli-narin among duodenum, jejunum, ileum and colon parts were 0.505 1 ± 0.192 7, 0.936 0 ± 0.187 2, 0.732 0 ±0.133 5, 0.251 3 ± 0.027 6 (μg·h-1·cm-2). The absorption rate constant of pectolinarigenin among the duodenum, je-junum, ileum and colon were 0.059 1 ±0.008 3, 0.093 3 ±0.029 2, 0.112 3 ± 0.035 6, 0.029 4 ± 0.009 1 (μg·h-1·cm-2). It was concluded that the absorption of both ingredients increased over time. The absorption of both ingredi-ents in the jejunum and ileum was higher than other parts of the small intestine. The absorption rate of pectolinarin in the entire small intestine was much higher than the absorption rate of pectolinarigenin.
