The study of brain structural in adolescents first-episode depression
10.3969/j.issn.1002-1671.2014.04.001
- VernacularTitle:青少年首发抑郁症患者大脑结构异常的研究
- Author:
Wei WANG
;
Ce CHEN
;
Hongmei WANG
;
Min JIA
;
Chengge GAO
;
Ming ZHANG
- Publication Type:Journal Article
- Keywords:
adolescent;
depression;
hamilton depression scale;
magnetic resonance imaging
- From:
Journal of Practical Radiology
2014;(4):543-546
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the morphological changes of the brain structure in youngsters first-episode depression.Methods Collecting 1 6 youngsters patients with first-episode depression and 1 6 healthy volunteers,separately examining morphological changes in their brain regions by MRI,and then analyzing data by Voxel-Based Morphometry in order to observe the damaged brain areas in depression patients.Results Comparing with control group,gray mater volume of the left dorsolateral prefrontal cortex and right fusiform gyrus decreased in depression patients.The gray matter density of left dorsolateral prefrontal cortex showed negative correlation with HAMD scores.Conclusion The gray matter decreased in left dorsolateral prefrontal cortex and right fusiform gyrus in youngsters first-episode depression patients.In addition,the gray matter density of left dorsolateral prefrontal cortex had negative correlation with HAMD scores.
