Research progress on peritumoral edema-related molecular biology factors of the metastasis tumor of brain
10.3969/j.issn.1000-8179.20132122
- VernacularTitle:脑转移瘤瘤周水肿相关分子生物学因素研究进展
- Author:
Jia GAO
;
Yanhui LIU
;
Ling YAN
;
Xiaocen CHEN
;
Lujun ZHAO
- Publication Type:Journal Article
- Keywords:
metastasis tumor of brain;
peritumoral edema;
molecular biology;
research progress
- From:
Chinese Journal of Clinical Oncology
2014;(8):534-537
- CountryChina
- Language:Chinese
-
Abstract:
Peritumoral edema (PTE) of the metastasis tumor of brain (MTB) refers to the abnormal increase of moisture in the surrounding cerebral parenchyma of the brain tumor. The mechanism of PTE occurrence of MTB is complicated, and the influencing factors are diverse. PTE is one of the key factors that affect patient survival and cure. Researchers from China and overseas believe that it may be related to the expression of the vascular endothelial growth factor (VEGF) or VEGF receptor, aquaporin-4 (AQP-4), matrix metalloproteinase-9, interleukin-6, hypoxia inducible factor-1a, and other molecular biology factors. Studies of these molecular biologi-cal factors provide objective scientific evidence for the prevention, control, monitoring, treatment, and prognosis of PTE of metasta-sized brain tumor. In addition to the traditional dehydration therapy of PTE, the use of PTE-related molecular biological factors pro-vides a new approach for the treatment. AQP-4 agonists or antagonists and VEGF receptor antagonists also have good therapeutic poten-tials. In this paper, the authors reviewed the PTE-related molecular biological factors of MTB.
