Relationship between the expression of BRCA1 and TUBB3 in patients with advanced non-small-cell lung cancer and its efficacy to platinum-based chemotherapy

VernacularTitle:BRCA1、TUBB3在晚期非小细胞肺癌中的表达及与铂类疗效的关系
Author: Fangfang RUAN ; Weimei JIANG
Publication Type:Journal Article
Keywords: Carcinoma,non-small-cell lung; BRCA1; TUBB3; Platinum-resistance; Efficacy
From: The Journal of Practical Medicine 2014;(5):732-734
CountryChina
Language:Chinese
Abstract: Objective To investigate the relationship between the expression of BRCA1,β-tubulin III (TUBB3) and their efficacies with platinum-based chemotherapy in patients with advanced non-small-cell lung cancer (NSCLC). Methods The expression levels of BRCA1 and TUBB3 were detected by immunohistochemistry. The relationship between BRCA1 and TUBB3 expressions and their efficacies were analyzed. Results The high expression rate of BRCA1 was 34.8%, and the efficacy of platinum-based chemotherapy in patients with BRCA1-lower expression is obviously better than that in patients with BRCA1-higher expression. There was a significant difference between these two groups (30.4%vs 67.4%, P=0.004). The effective rate of platinum-based chemotherapy in TUBB3-higher expression group and TUBB3-lower expression group were illustrated no significance (59.4% vs 50.0%, P=0.445). Conclusion Platinum-based chemotherapy is more suitable for the advanced NSCLC patients with lower expression of BRCA1. The expression level of BRCA1 could be used to predict the efficacy of platinum-based chemotherapy in advanced NSCLC patients.