Clinical analysis of theraPeutic Effects of umbilical cord mesenchymal stem cells transPlantation for Patients with refractory systemic luPus erythematosus
10.3969/j.issn.1006-5725.2014.05.019
- VernacularTitle:脐带间充质干细胞治疗难治性系统性红斑狼疮临床分析
- Author:
Guixian YANG
;
Liping PAN
;
Wei SONG
;
Qiaoyan ZHOU
;
Zhiqin CHEN
;
Yanbo WU
;
Xi WANG
;
Xiaocheng WANG
;
Qiang CHEN
- Publication Type:Journal Article
- Keywords:
Systemic luPus erythemamosus;
Umbilical cord-mesenchymal stem cells;
TrasPlantation
- From:
The Journal of Practical Medicine
2014;(5):735-738
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects and security of umbilical cord mesenchymal stem cells transPlantation (UC-MSCs) for Patients with refractory systemic luPus erythematosus(SLE). Methods Forty Patients with refractory SLE were divided into two grouPs at random.All of Patients were treated for glucocorticoid and CTX, then Patients of the 2 grouP were transPlanted for UC-MSCs.All of Patients were observed before and 2 weeks after treatment,1 month,2 months,3 months,6 months,9 months and 12 months of clinical manifestations and laboratory Parameters . Results 2 weeks after treatment, 60%of the 1 grouP were SLEDAI<10 scores, and the 2 grouPs were 90%. There was statistically significant difference between the two grouPs (χ2=7.619, P=0.006). 1 year after treatment, PLT,ALB and C3 of the 2 grouPs were more than the 1 grouPs(P<0.05). SLEDAI,U-Pro,ESR and Hs-CRP of the 1 grouPs were more than the 2 grouPs(P<0.05). WBC,Cr and C4 of the two grouPs had not statistically significant difference(P﹥0.05). The recurrence rate of the 1 grouPs was 45%. Of the 2 grouPs was 15%.There was statistically significant difference between the two grouPs (χ2=4.286, P=0.038). Conclusion It is effective and safe for refractory SLE to transPlant UC-MSCs after using glucocorticoid and CTX. Further observation is required to evaluate long term efficacy and adverse reaction of UC-MSCs.
