Clinical observation after Roux-en-Y gastric bypass in type 2 diabetes mellitus
10.3969/j.issn.1006-5725.2014.05.038
- VernacularTitle:2型糖尿病患者胃转流术后临床疗效观察
- Author:
Shitao HU
;
Ruixiang DUAN
;
Yong ZHANG
;
Dong WANG
;
Linlin XU
;
Xiaoli WANG
;
Hong JI
;
Haiqin RONG
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,type 2;
Roux-en-Y gastric bypass;
Post-operative evaluation
- From:
The Journal of Practical Medicine
2014;(5):792-795
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe multiple metabolic changes within one year after Roux-en-Y gastric bypass (RYGB) surgery in obese patients with type 2 diabetes mellitus, and to evaluate the index of the gastric bypass surgery and the determination of applicable population. Methods The clinical and laboratory data before and after surgery in 112 patients diagnosed as type 2 diabetes mellitus by RYGB were included in this study. According to BMI, these patients were divided into two groups: normal group (≤ 25kg/m2), and the overweight group (> 25 kg/m2). The physiologic and biochemical indexes of the patients were followed up at 1, 3, 6, 12 months, respectively. The statistical analysis was performed by SPSS17.0 software. Results Compared with the preoperative period, the levels of HbA1c and HOMA-IR in the postoperative period were significantly increased in the two groups. Principal component analysis showed that the postoperatively contributions of BMI and HbA1c in 6 months was bigger than that of the other indexes, while HOMA-β, HOMA-IR had larger contributions after 6-month postoperative period. Conclusion Various metabolic indexes in patients with type 2 diabetes improve significantly within one year after surgery, and the complete remission rate is gradually increased. The indexes including weight, blood glucose, serum lipids, HOMA-βand HOMA-IR in overweight and obese group have more significant improvements than those in normal group. Obese patients are more appropriate for the surgical treatment. The indexes, such as BMI, HbA1c,HOMA-βand HOMA-IR, should help to evaluate the operating effectiveness and preoperative indications.
