The value of MCV,MCH in the screening of thalassemia
10.3969/j.issn.1673-4130.2014.08.008
- VernacularTitle:MCV 、MCH检测在地中海贫血筛查中的应用研究
- Author:
Dongwei LIANG
;
Rongchuan LI
;
Jian HE
;
Zhenhong ZHANG
;
Weiming ZHENG
- Publication Type:Journal Article
- Keywords:
mean corpuscular volume;
mean corpuscular hemoglobin;
screening of thalassemia
- From:
International Journal of Laboratory Medicine
2014;(8):960-961
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the value of the tests of mean corpuscular volume (MCV ) ,mean corpuscular hemoglobin (MCH) in the screening of thalassemia .Methods 603 cases were performed MCV and MCH tests and gene detection of thalasse-mia .The results of gene detection were used as reference standard .The sensitivity ,specificity ,accuracy ,positive predictive value and negative predictive value of single or combined results of MCV ,MCH tests were calculated .Results The sensitivity and specificity of single MCV test were 91 .2% and 76 .1% ,single MCH test were 91 .2% and 70 .7% .The sensitivity and specificity of parallel combined tests of MCV and MCH were 94 .8% and 61 .4% ,serial combined tests of MCV and MCH were 88 .4% and 75 .6% .Con-clusion The sensitivity of single MCV or MCH test in the screening of thalassemia is high .Parallel combined tests of MCV and MCH can improve the sensitivity ,and will be widely used in the in the screening of thalassemia .
