Study on the relationship of omentin-1 in coronary heart disease patients with different glucose tolerance
10.3969/j.issn.1006-5725.2014.04.013
- VernacularTitle:网膜素-1在不同糖耐量水平合并冠心病患者中的相关性
- Author:
Chunmei LIAO
;
Wei MA
- Publication Type:Journal Article
- Keywords:
Coronary heart disease;
Omentin-1;
Insulin resistance;
Type 2 diabetes mellitus
- From:
The Journal of Practical Medicine
2014;(4):542-545
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between omentin-1 and Coronary heart disease in different glucose tolerance populations. Methods Serum omentin-1 levels were determined by ELISA in 143 subjects with normal glucose tolerance,impaired glucose tolerance with CHD, type 2 diabetes mellitus with CHD. The relationships between omentin-1 and waist- to-hip ratio, body mass index (BMI), blood Glucose, serum insulin,HOMA-IR and blood fat were also explored.Coronary artery stenosis was screnned by coronary interventional angiography and assessed by Gensini scoring system. Results Serum omentin-1 levels were all lower in T2DM and IGT subjects than those in control subjects (P<0.01). Serum omentin-1 was correlated positively with high density lipoprotein-cholesterol (P < 0.01),and inversely with body mass index,waist-hip ratio,diastolic blood pressure, triglyceride,fasting blood glucose,fasting insulin,HbA1c,[w1]and insulin resistance(HOMA-IR)(P<0.05 or P <0.01).Omentin-1 levels was negative related with Gensini coronary artery score (P < 0.01). Multiple linear regression showed body mass index,HOMA-IR,diastolic blood pressure were independently associated with omentin-1 levels (P<0.05 or P<0.01). Conclusions Serum omentin-1 levels, associated with fat,insulin sensitivity, are likely to play an important role in insulin resistance and the development of CHD in populations with different glucose tolerance.
