Relation between serum Apelin level and insulin resistance in infertility patients with polycystic ovarian syndrome
10.3969/j.issn.1006-5725.2014.04.016
- VernacularTitle:多囊卵巢综合征不孕患者血清Apelin水平与胰岛素抵抗的关系
- Author:
Hongyi HUANG
;
Yun MO
;
Bing HE
;
Yanghua LIU
;
Tuanying ZHANG
;
Fenglan ZHANG
- Publication Type:Journal Article
- Keywords:
Polycystic ovary syndrome;
Insulin resistance;
Infertility;
Apelin
- From:
The Journal of Practical Medicine
2014;(4):551-553
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the change of serum Apelin level and its relationship with insulin resistance (IR) in infertility patients with polycystic ovarian syndrome (PCOS). Methods Ninety-eight infertility patients with PCOS (PCOS group) and 72 infertility patients without PCOS (non-PCOS group) visiting our hospital for the first time from January 2011 to June 2012 were selected. The BMI , serum Apelin level (detected by ELISA), fasting blood glucose (FPG, detected by glucose oxidase method), fasting insulin (Fins, detected by chemiluminescence), and homeostasis model assessment of insulin resistance index (HOMA-IR) of the two groups were detected. Results The serum Apelin level and HOMA-IR in PCOS patients were higher than those in non-PCOS patients (3.28 ± 1.24 vs. 1.94 ± 0.78, P < 0.05; 3.84 ± 1.23 vs. 2.14 ± 0.77,P < 0.05). Pearson correlation analysis showed that serum Apelin level was positively correlated with HOMA-IR in PCOS patients (r=0.65, P<0.01). Conclusions The serum Apelin level in infertility patients with PCOS increased evidently, and was positively correlated with HOMA-IR; which indicated that Apelin may involve in the development of IR in infertility patients with PCOS.
