Use of high dose pralidoxime contribute to reduce mortality rate of organophosphate poisoning
- Author:
Pham -- Due
- Publication Type:Journal Article
- Keywords:
organophosphate poisoning
- MeSH:
Phosphoric Acid Esters;
Mortality;
Phosphoric Acid Esters;
Poisoning
- From:Journal of Vietnamese Medicine
2005;311(6):51-57
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
The research of 108 patients taken organophosphate to kill oneself who were treated by the new regimen in which, pralidoxime (PAM) were indicated according to poisoning level and adjusted by two factors: the change of plasma ChE and the adjustment of essential atropine dose. The results were compared with control groups including 54 patients treated by old regimen. Age, sex and ChE activity characteristics in 2 groups when hospitalized were the same. Compared with control group, the patients of study group received higher doses of PAM. The doses are very different between the patients depending on poisoning level. Therefore, predictive indicators in patient group were better than controlled group, especially the mortality rate (1.85% vs. 13%). The regimen achieved good results
