Pharmacodynamics comparative of cis-atracurium intermittent bolus injected according to real body weight and fat-free mass
10.3969/j.issn.1006-5725.2014.04.037
- VernacularTitle:顺苯磺酸阿曲库铵按无脂肪体重与实际体重间断静注给药药效学的对比研究
- Author:
Hanwen CHEN
;
Kai MO
;
Zhongjie LIU
;
Hui LIU
;
Qibo LIANG
;
Shiyuan XU
- Publication Type:Journal Article
- Keywords:
Cis-atracurium;
Fat-free mass;
Pharmacodynamics
- From:
The Journal of Practical Medicine
2014;(4):609-612
- CountryChina
- Language:Chinese
-
Abstract:
Ojective To compara the individual differences and clinical efficacy of cis-atracurium intermittent bolus injected according to fat-free mass and real body weight. Methods Forty patients (ASAI-II) who had no neuromuscular disease and underwent selective abdominal surgery under general anesthesia were randomly divided into group FFM (n=20) and group RBW(n=20) according to the different administration method. The responses of adductor pollicis to train-of-four (TOF) stimulation were monitored. Anesthesia was induced with propofol 2 mg/kg, fentanyl 3 ug/kg, cis-atracurium 129.6μg/kg (group FFM) or 100μg /kg (group RBW),and maintained with propofol and fentanyl given by target-controlled infusion. Intubation was attempted when T1 reached maximal inhibition. When the TOF stimulus T1 recovery to 5%, both group additional cis-atracurium 64.8 μg/kg (group FFM) or 50μg /kg (group RBW). The onset time, nonresponsive time, clinical duration, recovery index, pharmacological duration, cis-atracurium consumption, interval and frequency were recorded. Results No significant differences were found in general, interval, frequency,onset time, clinical duration, nonresponsive time,recovery index, pharmacological duration between the two groups (P > 0.05); There were significant differences in the cisatracurium consumption between two groups (P < 0.05); Compare with the group RBW, the differences of pharmacological duration and nonresponsive time between different individuals in group FFM were smaller (P < 0.05). Conclusion It can reduce the individual differences of muscle relaxant effect to apply cis-atracurium and cis-atracurium consumption according to fat-free mass.
