Affective of EGR2 expression in Schwann cells line exposed in high glucose
10.3969/j.issn.1673-4130.2014.08.001
- VernacularTitle:高糖培养对神经膜细胞株 EG R2蛋白表达的影响及其意义
- Author:
Hua ZHANG
;
Yanli LIU
;
Xueqin HE
;
Xinghui LIU
- Publication Type:Journal Article
- Keywords:
high glucose;
Schwann cells;
diabetes
- From:
International Journal of Laboratory Medicine
2014;(8):945-946
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of different glucose concentration on EGR2 protein expression in Schwann cells . Methods Schwann cells were cultured in different glucose concentrations ,and they were divided into two groups ,normal glucose concentration (5 .5 mmol/L ,N group) and high glucose concentration(25 mmol/L ,H group) .Immunocytochemistry and Western blot were used to study EGR2 expression .Results The expression of EGR2 protein was higher in H group than that in N group the difference was statistically significont (P<0 .05) .Conclusion High glucose can lead to EGR2 protein upregulate in Schwann cells ,and EGR2 maybe one of the reasons of diabetic neuropathy .
