Application of the measurement of Cys-c,Fbg and U-mALB in the early renal damage of diabetes
10.3969/j.issn.1673-4130.2014.08.005
- VernacularTitle:Cys-C、Fbg、U-m ALB检测在糖尿病早期肾损害中的应用
- Author:
Shien ZHANG
;
Yiyuan HOU
- Publication Type:Journal Article
- Keywords:
cystatin C;
fibrinogen;
diabetes;
early renal damage
- From:
International Journal of Laboratory Medicine
2014;(8):954-955
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the applied value of combined measurement of cystatin c (Cys-C) ,fibrinogen(Fbg) and U-mALB in early renal damage due to diabetes .Methods 97 cases of type Ⅱ diabetes mellitus (T2DM ) patients were divided into 2 groups according to the measured glycated hemoglobin HbA 1c ,serum glucose well control group (46 cases ,HbA1c≤8% ) ,and ser-um glucose poor control group (51 cases ,HbA1c>8% ) .39 healthy people were randomly selected as control group .The concentra-tion of Cys-C ,Fbg and U-mALB were detected .Results Cys-C ,Fbg and U-mALB of serum glucose poor control group were higher than that of glucose well control group and control group (P<0 .01) .Cys-C and U-mALB of glucose well control group were high-er than the control group (P<0 .01) .As a single positive marker of diagnosis ,the sensitivity for serum Cys-C ,serum Fbg ,and U-mALB were 73 .6% ,71 .4% and 61 .5 % respectively .The positive rate of combined detection was 97 .0% ,which was significantly higher than that of the individual testing (P<0 .05) .Conclusion Combined measurement of Cys-C ,Fbg and U-mALB has impor-tant clinical value for diagnosis and condition monitoring in early renal damage .
