Protective Effects of Ethanol Extracts of Calonyction Acculeatum Beans on Rats with Acute Lung Injury

VernacularTitle:月光花豆乙醇提取物对急性肺损伤大鼠的保护作用
Author: Xiuneng TANG ; Hongmian WEI ; Renbin HUANG
Publication Type:Journal Article
Keywords: Ethanol extract of calonyction acculeatum beans; Lung injury,acute; Nuclear factor; Interleukin
From: Herald of Medicine 2014;(5):569-572
CountryChina
Language:Chinese
Abstract: Objective To investigate the protective effects of ethanol extract of calonyction acculeatum beans( CABE) on rats with acute lung injury ( ALI ) . Methods The ALI model was induced via intravenous injection with 5 mg · kg-1 lipopolysaccharide(LPS). The expression of nuclear factor-кB p65(NF-кB65) was determind by immunohistochemistry(IHC), and the content of interleukin-1β( IL-1β) in the lung tissue was detected by enzyme-linked immunosorbent assay ( ELISA ) . Meanwhile,lung tissue histopathology,the wet-dry weight ratio of lung and the activity of myeloperoxidase(MPO) in the lung tissues were observed. Results Compared with the model group, CABE lessened the lung injury, decreased IL-1β level, reduced the lung dry-wet weight ratio and activity of MPO,and down-regulated the expression of NF-кB/p65(P<0. 05). Conclusion CABE has remarkedly protective effect on ALI induced by LPS in rats. One of the mechanisms may be related to reducing the secretion of IL-1β and interfering with the activity of NF-кB.