Clinical study of therapeutic effect of benazepril on nonproliferative diabetic retinopathy
10.3760/cma.j.issn.1008-1372.2014.04.005
- VernacularTitle:贝那普利治疗非增生期糖尿病视网膜病变的临床研究
- Author:
Shan HUA
;
Jiya WANG
- Publication Type:Journal Article
- Keywords:
Benzazepines/therapeutic use;
Diabetic retinopathy/drug therapy
- From:
Journal of Chinese Physician
2014;(4):447-449
- CountryChina
- Language:Chinese
-
Abstract:
Ojectvie To investigate therapeutic effect of benazepril on nonproliferative diabetic retinopathy ( NPDR) .Meth-ods Twenty nine patients with early diabetic nephropathy complicated with type 2 diabetes and NPDR were randomly divided into benazepril group ( n =12) and conventional therapy control group ( n =17).The changes of blood pressure , blood glucose, glycosy-lated hemoglobin , blood creatinine , urinary albumin , best corrected visual acuity ( BCVA ) , and fluorescein fundus angiography ( FFA) were observed before and after 3 and 6 months of treatment .Results After 3 months of treatment by benazepril , all laboratory detection parameters were no significant difference compared with before treatment and conventional therapy control group ( P >0.05);While after 6 months, compared with before treatment and control group , blood pressure, blood glucose, glycosylated hemoglo-bin, blood creatinine , and urinary albumin were significantly decreased ( P <0.05 ); According to the results of BCVA and FFA , progression of pathological changes of NPDR were significantly slower in benazepril group compared with control group ( P <0.05 ) . Conclusions Benazepril has some protection effect for NPDR to delay NPDR development and decrease serious complications .
