The clinical significance on changes of plasma fibrinogen,plasminogen and D-dimmer before and after thrombolytic therapy in patients with acute myocardial infarction
10.3969/j.issn.1673-4130.2014.08.007
- VernacularTitle:急性心梗患者溶栓治疗前后血浆纤维蛋白原、纤溶酶原和D-二聚体水平变化及临床意义
- Author:
Shen WEI
;
Jiedan CAI
;
Hongli GAO
;
Chuzhong ZHENG
;
Wanling ZHANG
;
Wanbing TANG
- Publication Type:Journal Article
- Keywords:
myocardial infarction;
fibrinogen;
plasminogen;
D-dimmer;
thrombolytic
- From:
International Journal of Laboratory Medicine
2014;(8):958-959
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the changes of plasma fibrinogen ,plasminogen and D-dimmer before and after thrombolytic therapy in patients with acute myocardial infarction (AMI) ,to provide the evidence for treatment and prognosis AMI .Methods 93 cases of patients with AMI were divided into twe groups ,reperfusion group of 77 cases ,obstract group of 16 cases .At the same pe-riod ,30 cases myocardial infarction of patients with non thrombolytic therapy were selected as control group .The levels of plasma Fib ,Plg and D-dimer in each group were detected at different times .Results The levels of Fib and D-D in AMI patients were higher than those in the control group before thrombolysis therapy (P<0 .05) .Compared with before thrombolysis therapy ,the Fib and Plg levels of AMI patients were decreased significantly after thrombolytic therapy 6 h(P<0 .01) ,and returned to the normal level after 48 h .The D-dimmer level of AMI patients was increased significantly after thrombolytic therapy 6 h(P<0 .01) ,and returned to the normal level after 7 d .After thrombolytic therapy 6 h ,the levels of Fib and Plg of reperfusion group were decreased signifi-cantly(P<0 .05) ,the level of D-dimmer was increased significantly (P<0 .05) .Conclusion The levels of plasma fibrinogen ,plas-minogen and D-dimmer have important reference value for monitor the thrombolytic therapy effect in patients with AMI .
