Effects of Xuanzhi Analgesic Tablet on Plasma Levels of 6-K-PGFlαand TXB2 in Rats with Acute Blood Stasis
10.3870/yydb.2014.05.006
- VernacularTitle:玄芷镇痛片对急性血瘀模型大鼠血浆6-酮-前列腺素Flα和血栓素B2的影响
- Author:
Xin ZOU
;
Kaifu WANG
;
Lijun XU
;
Di GONG
;
Guangying HUANG
- Publication Type:Journal Article
- Keywords:
Xuanzhi analgesic tablet;
Blood stasis,acute;
6-keto-prostaglandin Flα;
Thromboxane B2
- From:
Herald of Medicine
2014;(5):573-574
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of xuanzhi analgesic tablets on plasma levels of 6-keto-prostaglandin Flα(6-K-PGFlα) and thromboxane B2(TXB2) in rats with acute blood stasis. Methods Sixty SD rats were divided into six groups randomly, namely normal control, model control, positive control, xuanzhi analgesic tablets at 1. 36, 2. 72, and 5. 44 g·kg-1 groups. The rat model of blood stasis syndrome was caused by subcutaneous injection of adrenaline incorporated with ice-bathing. The effects of xuanzhi analgesic tablet on 6-K-PGFlαand TXB2 were observed. Results Compared with the normal control,plasma level of 6-K-PGFlα was significantly reduced(P<0. 01) and that of TXB2 in the model control was evidently increased(P<0. 01). Three dosages of xuanzhi analgesic tablets significantly raised 6-K-PGFlαlevel(P<0. 05)and lowered TXB2 level (P<0. 05). Conclusion Xuanzhi analgesic tablets significantly adjust plasma levels of 6-K-PGFlαand TXB2in rats with acute blood stasis. Xuanzhi analgesic tablets can coreect the imbalance between PGI2 and TXA2 through increasing 6-K-PGFlαand desearing TXB2 levels.
