Study on the relationship of urinary liver-type fatty-acid binding protein and progression of nephropathy in diabetic patients
10.3760/cma.j.issn.1008-1372.2014.04.012
- VernacularTitle:尿肝型脂肪酸结合蛋白与糖尿病肾病进展的关系研究
- Author:
Xuehui ZENG
;
Zhongxin LI
;
Chunlei ZHANG
;
Linli SONG
- Publication Type:Journal Article
- Keywords:
Diabetic nephropathies/metabolism;
Fatty acid-binding proteins;
Creatinine/metabolism;
Hemoglobin A,glyco-sylated/metabolism;
Hemoglobins/metabolism;
Albumins/metabolism
- From:
Journal of Chinese Physician
2014;(4):468-470
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship of urinary liver-type fatty-acid binding protein and progression of ne-phropathy in diabetic patients .Methods A total of 132 cases of type 1 and type 2 diabetic patients were recruited in this study , and were divided into four groups based on the urine albumin /creatinine and serum creatinine levels , including normal albuminuria group ( n =45), microalbuminuria group ( n =36), clinical albuminuria group ( n =30), and renal failure group ( n =21), Additional 65 healthy subjects were recruited as control group .The levels of urinary liver-type fatty-acid binding protein ( L-FABP) were measured with enzyme-linked immunosorbent assay (ELISA), and serum creatinine, urine creatinine, Liver function, hemoglobin, glycated he-moglobin (HbA1c), albumin (Alb), and 24h urinary protein were measured by respective biochemical or immunological methods . Results With the progression of diabetic nephropathy , the level of urinary L-FABP was gradually increased ( P <0.01 ) , subgroup analysis showed that the level of urine L-FABP of normal albuminuria group was significantly higher than that of healthy group ( P <0.05 ) .The level of urine L-FABP of microalbuminuria group was significantly higher than that of normal albuminuria group ( P <0.01 ) .The level of urine L-FABP of clinical albuminuria group was significantly higher than that of microalbuminuria group ( P <0.01 ) .The level of urine L-FABP of renal failure group was significantly higher than that of clinical albuminuria group ( P <0.01 ) . The levels of urinary L-FABP was negatively correlated with estimated glomerular filtration rate ( eGFR) ( r =-0.812 , P <0.01 ) , was positively correlated with Scr ( r =0.901, P <0.01), and was no correlation with HbA1c ( P >0.05).Conclusions The uri-nary L-FABP level can predict the occurrence of early diabetic nephropathy , and also monitor the progression of diabetic nephropathy .
