Effects of Enteral Nutrition on Inflammatory Factors and Cardiac Function in Elderly Malnourished Patients with Heart Failure
10.3870/yydb.2014.05.010
- VernacularTitle:肠内营养液对营养不良老年心力衰竭患者炎性因子及心功能的影响
- Author:
Dan ZHOU
;
Honglian ZHOU
;
Hongbo ZHENG
;
Yali WU
- Publication Type:Journal Article
- Keywords:
Enteral nutrition;
Heart failure,elderly;
Inflammatory factors;
Cardiac function
- From:
Herald of Medicine
2014;(5):586-589
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of enteral nutrition( EN) on inflammatory factors and cardiac function in elderly patients with heart failure ( HF ) . Methods A total of 96 elderly patients with HF were enrolled in this study and randomly divided into treatment group A,treatment group B and control group( n= 32 in each group) . Patients in group A were provided with 500 mL of EN daily for 1 month, and those in group B were provided with the same dose of EN for 3 months. Control group was treated with normal diet. The nutrition status of each group was assessed by NRS2002. Meanwhile,all patients were evaluated by New York Heart Association(NYHA) class and left ventricle eject fraction(LVEF). The levels of BNP,IL-6, CRP and TNF-α were also measured before and after nutrition treatment. Results In group A and group B,BMI,TSF,AMC, TP,ALB and HGB increased. Symptoms of HF alleviated quickly and LVEF increased compared to the baseline. The levels of BNP,IL-6,CRP and TNF-α were significantly lower after treatment(P<0. 05) in both treatment groups,and the change in group B was more obvious(P<0. 01) than group A. However,in control group,there is neither evident improvement in cardiac function or nutrition status,nor in inflammatory factor levels. Conclusion Adding EN support to the normal treatment of heart failure in elderly malnourished patients with HF not only improves the function of heart and nutrition status, but also helps to support immune system so as to alleviate acute inflammatory response. The benefits from EN depend on the duration of therapy.
